Ausgewählte Veröffentlichungen der Arbeitsgruppe der letzten Jahre:

Emerging Agents for the Treatment of Advanced, Imatinib-Resistant Gastrointestinal Stromal Tumors: Current Status and Future Directions. Bauer S, Joensuu H. Drugs. 2015 Jul 18.

TNF-alpha and melphalan-based isolated limb perfusion: no evidence supporting the early destruction of tumour vasculature. Podleska LE, Funk K, Umutlu L, Grabellus F, Taeger G, de Groot H. Br J Cancer. 2015 Aug 11;113(4):645-652. doi: 10.1038/bjc.2015.246. Epub 2015 Jul 14.

Covalent-Allosteric Kinase Inhibitors. Weisner J, Gontla R, van der Westhuizen L, Oeck S, Ketzer J, Janning P, Richters A, Mühlenberg T, Fang Z, Taher A, Jendrossek V, Pelly SC, Bauer S, van Otterlo WA, Rauh D. Angew Chem Int Ed Engl. 2015 Jun 25. doi: 10.1002/anie.201502142. [Epub ahead of print]

Pediatric second primary malignancies after retinoblastoma treatment. Temming P, Viehmann A, Arendt M, Eisele L, Spix C, Bornfeld N, Sauerwein W, Jöckel KH, Lohmann DR. Pediatr Blood Cancer. 2015 May 13. doi: 10.1002/pbc.25576. [Epub ahead of print]

miRNA-221 and miRNA-222 induce apoptosis via the KIT/AKT signalling pathway in gastrointestinal stromal tumours.Ihle MA, Trautmann M, Kuenstlinger H, Huss S, Heydt C, Fassunke J, Wardelmann E, Bauer S, Schildhaus HU, Buettner R, Merkelbach-Bruse S. Mol Oncol. 2015 Aug;9(7):1421-33. doi: 10.1016/j.molonc.2015.03.013. Epub 2015 Apr 10.

Inhibition of KIT-glycosylation by 2-deoxyglucose abrogates KIT-signaling and combination with ABT-263 synergistically induces apoptosis in gastrointestinal stromal tumor. Mühlenberg T, Grunewald S, Treckmann J, Podleska L, Schuler M, Fletcher JA, Bauer S. PLoS One. 2015 Mar 17;10(3):e0120531. doi: 10.1371/journal.pone.0120531. eCollection 2015.

[Gastrointestinal stromal tumours (GIST)--development in pathology, surgery and medical therapy. Developed during the 10th German GIST-meeting, Göttingen]. Agaimy A, Bauer S, Beham A, Bertolini J, Haller F, Koschny R, Maier J, Montemurro M, Perez D, Schaefer IM, Schildhaus HU, Wurst C, Cameron S. Z Gastroenterol. 2015 Mar;53(3):235-43. doi: 10.1055/s-0034-1385711. Epub 2015 Mar 16. German.

[Sarcoma of the hand and wrist]. Steinau HU, Farzaliyev F, Stricker I, Hauser J, Podleska LE.

Handchir Mikrochir Plast Chir. 2015 Apr;47(2):76-82. doi: 10.1055/s-0034-1398527. Epub 2015 Mar 11. German.  

Ponatinib inhibits polyclonal drug-resistant KIT oncoproteins and shows therapeutic potential in heavily pretreated gastrointestinal stromal tumor (GIST) patients. Garner AP, Gozgit JM, Anjum R, Vodala S, Schrock A, Zhou T, Serrano C, Eilers G, Zhu M, Ketzer J, Wardwell S, Ning Y, Song Y, Kohlmann A, Wang F, Clackson T, Heinrich MC, Fletcher JA, Bauer S, Rivera VM. Clin Cancer Res. 2014 Nov 15;20(22):5745-55. doi: 10.1158/1078-0432.CCR-14-1397. Epub 2014 Sep 19.

Drug dosage in isolated limb perfusion: evaluation of a limb volume model for extremity volume calculation. Podleska LE, Poeppel T, Herbrik M, Dahlkamp L, Grabellus F, Taeger G. World J Surg Oncol. 2014 Apr 1;12:81. doi: 10.1186/1477-7819-12-81.

[Long-term functional results after sarcoma resection]. Steinau HU, Hauser J, Farzaliyev F, Podleska L. Chirurg. 2014 Mar;85(3):215-20, 222-3. doi: 10.1007/s00104-013-2603-z. Review. German.

Long-term follow-up of patients with GIST undergoing metastasectomy in the era of imatinib -- analysis of prognostic factors (EORTC-STBSG collaborative study). Bauer S, Rutkowski P, Hohenberger P, Miceli R, Fumagalli E, Siedlecki JA, Nguyen BP, Kerst M, Fiore M, Nyckowski P, Hoiczyk M, Cats A, Casali PG, Treckmann J, van Coevorden F, Gronchi A. Eur J Surg Oncol. 2014 Apr;40(4):412-9. doi: 10.1016/j.ejso.2013.12.020. Epub 2014 Jan 15.

Phase I study of panobinostat and imatinib in patients with treatment-refractory metastatic gastrointestinal stromal tumors. Bauer S, Hilger RA, Mühlenberg T, Grabellus F, Nagarajah J, Hoiczyk M, Reichardt A, Ahrens M, Reichardt P, Grunewald S, Scheulen ME, Pustowka A, Bock E, Schuler M, Pink D. Br J Cancer. 2014 Mar 4;110(5):1155-62. doi: 10.1038/bjc.2013.826. Epub 2014 Jan 16.

Brostallicin versus doxorubicin as first-line chemotherapy in patients with advanced or metastatic soft tissue sarcoma: an European Organisation for Research and Treatment of Cancer Soft Tissue and Bone Sarcoma Group randomised phase II and pharmacogenetic study. Gelderblom H, Blay JY, Seddon BM, Leahy M, Ray-Coquard I, Sleijfer S, Kerst JM, Rutkowski P, Bauer S, Ouali M, Marreaud S, van der Straaten RJ, Guchelaar HJ, Weitman SD, Hogendoorn PC, Hohenberger P. Eur J Cancer. 2014 Jan;50(2):388-96. doi: 10.1016/j.ejca.2013.10.002. Epub 2013 Nov 8.

Neoadjuvant imatinib in advanced primary or locally recurrent dermatofibrosarcoma protuberans: a multicenter phase II DeCOG trial with long-term follow-up.

Ugurel S, Mentzel T, Utikal J, Helmbold P, Mohr P, Pföhler C, Schiller M, Hauschild A, Hein R, Kämpgen E, Kellner I, Leverkus M, Becker JC, Ströbel P, Schadendorf D.  Clin Cancer Res. 2014 Jan 15;20(2):499-510. doi: 10.1158/1078-0432.CCR-13-1411. Epub 2013 Oct 30.

Liposarcomas. Henze J, Bauer S. Hematol Oncol Clin North Am. 2013 Oct;27(5):939-55. doi: 10.1016/j.hoc.2013.07.010. Review

[Adjuvant chemotherapy for soft tissue sarcoma? a clear no - well - yes-ish]. Abendroth A, Bauer S. Dtsch Med Wochenschr. 2013 Oct;138(41):2107-10. doi: 10.1055/s-0033-1349604. Epub 2013 Oct 1. German. No abstract available.

TERT promoter mutations are frequent in atypical fibroxanthomas and pleomorphic dermal sarcomas. Griewank KG, Schilling B, Murali R, Bielefeld N, Schwamborn M, Sucker A, Zimmer L, Hillen U, Schaller J, Brenn T, Schadendorf D, Mentzel T. Mod Pathol. 2014 Apr;27(4):502-8. doi: 10.1038/modpathol.2013.168. Epub 2013 Sep 13.

The pathologic response of resected synovial sarcomas to hyperthermic isolated limb perfusion with melphalan and TNF-α: a comparison with the whole group of resected soft tissue sarcomas. Schwindenhammer B, Podleska LE, Kutritz A, Bauer S, Sheu SY, Taeger G, Schmid KW, Grabellus F. World J Surg Oncol. 2013 Aug 12;11(1):185. doi: 10.1186/1477-7819-11-185.

Mammalian target of rapamycin pathway activity in alveolar soft part sarcoma. Reis H, Hager T, Wohlschlaeger J, Bauer S, Katenkamp K, Katenkamp D, Baba HA. Hum Pathol. 2013 Oct;44(10):2266-74. doi: 10.1016/j.humpath.2013.04.018. Epub 2013 Jul 17.

Trabectedin in metastatic soft tissue sarcomas: Role of pretreatment and age. Hoiczyk M, Grabellus F, Podleska L, Ahrens M, Schwindenhammer B, Taeger G, Pöttgen C, Schuler M, Bauer S. Int J Oncol. 2013 Jul;43(1):23-8. doi: 10.3892/ijo.2013.1928. Epub 2013 May 2.

DOG1 regulates growth and IGFBP5 in gastrointestinal stromal tumors. Simon S, Grabellus F, Ferrera L, Galietta L, Schwindenhammer B, Mühlenberg T, Taeger G, Eilers G, Treckmann J, Breitenbuecher F, Schuler M, Taguchi T, Fletcher JA, Bauer S. Cancer Res. 2013 Jun 15;73(12):3661-70. doi: 10.1158/0008-5472.CAN-12-3839. Epub 2013 Apr 10.

Neoadjuvant treatment improves capsular integrity and the width of the fibrous capsule of high-grade soft-tissue sarcomas. Grabellus F, Podleska LE, Sheu SY, Bauer S, Pöttgen C, Kloeters C, Hoiczyk M, Lauenstein TC, Schmid KW, Taeger G. Eur J Surg Oncol. 2013 Jan;39(1):61-7. doi: 10.1016/j.ejso.2012.10.009. Epub 2012 Oct 25.

Growth patterns of lung metastases from sarcoma: prognostic and surgical implications from histology. Welter S, Grabellus F, Bauer S, Schuler M, Eberhardt W, Tötsch M, Stamatis G. Interact Cardiovasc Thorac Surg. 2012 Oct;15(4):612-7. Epub 2012 Jul 3.

Megavoltage computed tomography image guidance with helical tomotherapy in patients with vertebral tumors: analysis of factors influencing interobserver variability. Levegrün S, Pöttgen C, Jawad JA, Berkovic K, Hepp R, Stuschke M. Int J Radiat Oncol Biol Phys. 2013 Feb 1;85(2):561-9. doi: 10.1016/j.ijrobp.2012.04.010. Epub 2012 May 30.

Size-based clinical response evaluation is insufficient to assess clinical response of sarcomas treated with isolated limb perfusion with TNF-α and melphalan. Grabellus F, Stylianou E, Umutlu L, Sheu SY, Lehmann N, Taeger G, Lauenstein TC. Ann Surg Oncol. 2012 Oct;19(11):3375-85. doi: 10.1245/s10434-012-2408-1. Epub 2012 May 24.

Growth patterns of lung metastases from sarcomas. Welter S, Grabellus F, Bauer S, Schmid KW, Stamatis G, Tötsch M. Virchows Arch. 2011 Aug;459(2):213-9. doi: 10.1007/s00428-011-1116-8. Epub 2011 Jul 6.

Tumor vascularization and histopathologic regression of soft tissue sarcomas treated with isolated limb perfusion with TNF-α and melphalan. Grabellus F, Kraft C, Sheu-Grabellus SY, Bauer S, Podleska LE, Lauenstein TC, Pöttgen C, Konik MJ, Schmid KW, Taeger G. J Surg Oncol. 2011 Apr;103(5):371-9. doi: 10.1002/jso.21724.

Increased shedding of soluble TNF-receptor 1 during hyperthermic TNF-α-based isolated limb perfusion. Grabellus F, Podleska LE, Bjerlestam S, Sheu SY, Lendemans S, Schmid KW, Taeger G. Int J Hyperthermia. 2011;27(1):33-41. doi: 10.3109/02656736.2010.508067. Epub 2010 Nov 12.

Proton beam therapy for childhood malignancies: status report. Timmermann B.

Klin Padiatr. 2010 May;222(3):127-33. doi: 10.1055/s-0030-1249657. Epub 2010 May 31. Review.

MET overexpressing chordomas frequently exhibit polysomy of chromosome 7 but no MET activation through sarcoma-specific gene fusions. Grabellus F, Konik MJ, Worm K, Sheu SY, van de Nes JA, Bauer S, Paulus W, Egensperger R, Schmid KW. Tumour Biol. 2010 Jun;31(3):157-63. doi: 10.1007/s13277-010-0021-0. Epub 2010 Mar 6.

Overexpression of the drug resistance-associated protein metallothionein does not correlate with response of sarcomas to isolated limb perfusion treatment. Grabellus F, Sheu SY, Tötsch M, Lehmann N, Kaiser GM, Jasani B, Taeger G, Schmid KW. J Surg Oncol. 2010 May 1;101(6):465-70. doi: 10.1002/jso.21513.

Role of N-acetyl-N-nitroso-tryptophan as nitric oxide donor in the modulation of HIF-1-dependent signaling. Berchner-Pfannschmidt U, Tug S, Hu J, Reyes BD, Fandrey J, Kirsch M. Biol Chem. 2010 May;391(5):533-40. doi: 10.1515/BC.2010.054.

Proapoptotic activity of bortezomib in gastrointestinal stromal tumor cells. Bauer S, Parry JA, Mühlenberg T, Brown MF, Seneviratne D, Chatterjee P, Chin A, Rubin BP, Kuan SF, Fletcher JA, Duensing S, Duensing A. Cancer Res. 2010 Jan 1;70(1):150-9. doi: 10.1158/0008-5472.CAN-09-1449. Epub 2009 Dec 22.

Inhibitors of deacetylases suppress oncogenic KIT signaling, acetylate HSP90, and induce apoptosis in gastrointestinal stromal tumors. Mühlenberg T, Zhang Y, Wagner AJ, Grabellus F, Bradner J, Taeger G, Lang H, Taguchi T, Schuler M, Fletcher JA, Bauer S. Cancer Res. 2009 Sep 1;69(17):6941-50. doi: 10.1158/0008-5472.CAN-08-4004. Epub 2009 Aug 25.

A three-gene signature for outcome in soft tissue sarcoma. Hoffmann AC, Danenberg KD, Taubert H, Danenberg PV, Wuerl P. Clin Cancer Res. 2009 Aug 15;15(16):5191-8. doi: 10.1158/1078-0432.CCR-08-2534. Epub 2009 Aug 11. Erratum in: Clin Cancer Res. 2009 Oct;15(20):6472. Hoffman, Andreas-Claudius [corrected to Hoffmann, Andreas-Claudius].

Evaluation of 47 soft tissue sarcoma resection specimens after isolated limb perfusion with TNF-alpha and melphalan: histologically characterized improved margins correlate with absence of recurrences. Grabellus F, Kraft C, Sheu SY, Ebeling P, Bauer S, Lendemans S, Schmid KW, Taeger G. Ann Surg Oncol. 2009 Mar;16(3):676-86. doi: 10.1245/s10434-008-0277-4. Epub 2009 Jan 6.

[Giant cell tumors of soft tissue arising in surgical scars]. Grabellus F, Sheu SY, Schmidt B, von Winterfeld F, Schoenfeld B, Taeger G, Hillen U, Schmid KW. Pathologe. 2009 Sep;30(5):401-6. doi: 10.1007/s00292-009-1142-3. German.